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Methodological Foundations of Biomedical Informatics Fall 2014 (BMSC-GA 4449)
Course Director: David Fenyö (David@FenyoLab.org)
Course Overview
This course provides an overview of foundational knowledge and essential methods relevant for all areas of biomedical informatics. Students will explore recurring themes and application domains most frequently used in the field. The course will be technical and rigorous, and it will include a number of computer science topics. The course content has been selected by the curriculum committee, and the topics will change over time. The majority of the coursework will be programming assignments and readings.
Learning objectives
The student will learn and understand the most commonly used methodologies in the field of biomedical informatics.
Course Assessment
- Programming Assignments (40%).
- Discussions (25%)
- Final Project (35%)
Course Topics
- Programming:
- Algorithms
- Linear Algebra
- Optimization
- Statistics
- Machine Learning
- Information Retrieval
- Data visualization
- Experimental design
- Signal Processing
- Pathways and Networks
- Modeling and Simulation
Lectures
In addition to the lectures listed below, the students should also attend the relevant lectures from Introduction to Biostatistics and Bioinformatics Fall 2014 (BMSC-GA 4451)
Lecture 1 Introduction (September 9, 2014 TRB 739 5pm)
Lecturer: Fenyo
Lecture 2 Algorithms (September 16, 2014 TRB 739 5pm)
Lecturer: Peskin & Fenyo
Homework (due date: December 16)
Reading List
The Algorithm Design Manual by Steven S Skiena, Chapters 1-4
Visualgo
Additional Reading
Rosalind, Algorithm Heights
Coursera: Algorithms Part I
Coursera: Algorithms Part II
Lecture 3 Linear Algebra (September 30, 2014 TRB 739 5pm)
Lecturer: Fenyo
Homework (due date: December 16)
Reading List
Quick Review of Matrix and Real Linear Algebra by KC Border
Additional Reading
Coursera: Coding the Matrix
Lecture 4 Optimization (October 7, 2014 TRB 739 5pm)
Lecturer: Fenyo
Homework (due date: December 16)
Reading List
An Introduction to Optimization Chapers 6-9, 19, 20
Additional Reading
Coursera: Linear and Discrete Optimization
Lecture 5 Statistics (October 14, 2014 TRB 739 5pm)
Lecturer: Fenyo
Homework (due date: December 16)
Reading List
All of Statistics by Larry Wasserman, Chapters 1-3
Let's Give Statistics the Attention it Deserves
Additional Reading
Think Stats by Allen B. Downey
Think Bayes by Allen B. Downey
An Introduction to Statistical Modeling of Extreme Values by Stuart Coles
All of Nonparametric statistics by Larry Wasserman
Lecture 6 Machine Learning and Information Retrieval (October 21, 2014 TRB 739 5pm)
Lecturer: Aphinyanaphongs & Fenyo
Homework (due date: December 16)
Reading List
An Introduction to Statistical Learning by Gareth James et al. Chapter 1-2
ROC Graphs: Notes and Practical Considerations for Researchers by Tom Fawcett
Information Retrieval by William Hersh Chapter 1-2
Additional Reading
Coursera: Machine Learning
A Gentle Introduction to Support Vector Machines in Biomedicine: Theory and Methods (Volume 1) by Alexander Statnikov et al.
A Gentle Introduction to Support Vector Machines in Biomedicine: Case Studies and Benchmarks (Volume 2) by Alexander Statnikov et al.
Lecture 7 Data visualization (October 30, 2014 TRB 739 5pm)
Lecturer: Fenyo
Reading List
Data visualization: A view of every Points of View column
Data Analysis with Open Source Tools by Philipp K. Janert
Additional Reading
The Wall Street Journal Guide to Information Graphics: The Dos and Don'ts of Presenting Data, Facts, and Figures
Visualize This: The FlowingData Guide to Design, Visualization, and Statistics by Nathan Yau
Lecture 8 Experimental design (November 11, 2014 TRB 739 5pm)
Lecturer: Fenyo
Reading List
Design and Analysis of Experiments by Douglas C. Montgomery
Adaptive clinical trials in oncology by Donald A. Berry, Nature Reviews Clinical Oncology 9 (2012) 199-207.
Bias as a threat to the validity of cancer molecular-marker research by David F. Ransohoff, Nat Rev Cancer 5 (2005) 142-149
Additional Reading
Essentials of Clinical Research by Stephen P. Glasser
Handbook for Good Clinical Research Practice (GPC - WHO)
Lecture 9 Signal Processing (November 18, 2014 TRB 739 5pm)
Lecturer: Fenyo
Additional Reading
Coursera Digital Signal Processing
Lecture 10 Pathways and Networks (December 2, 2014 TRB 739 5pm)
Lecturer: Fenyo
Reading List
All of Statistics by Larry Wasserman, Chapters 16-18
The Algorithm Design Manual by Steven S Skiena, Chapter 5
Additional Reading
An Introduction to Systems Biology: Design Principles of Biological Circuits by Uri Alon Chapters 1-4
Computational Modelling Of Gene Regulatory Networks - A Primer by Hamid Bolouri
Coursera: Probabilistic Graphical Models
Lecture 11 Modeling and Simulation (December 9, 2014 TRB 739 5pm)
Lecturer: Fenyo
Reading List
All of Statistics by Larry Wasserman, Chapters 23-24
Modeling Complex Systems by Nino Boccara Chapters 1-2
Additional Reading
Evolutionary Dynamics: Exploring the Equations of Life by Martin A. Nowak
Coursera: Dynamic Modeling Methods for Systems Biology
Monte Carlo Statistical Methods by Robert & Casella
Lecture 12 Project Presentation (December 12, 2014 TRB 739 2:30pm)
Lecturer: Fenyo
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