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Methods in Quantitive Biology (BMSC-GA 4449) and Methodological Foundations of BMI (BMIN-GA 1001) Fall 2017
Course Directors:
Kasthuri Kannan (Kasthuri.Kannan@nyumc.org)
David Fenyö (David@FenyoLab.org)
Course Overview
This course provides an overview of foundational knowledge and essential methods relevant for all areas of biomedical informatics. Students will explore recurring themes and application domains most frequently used in the field. The course will be technical and rigorous, and it will include a number of computer science topics. The course content has been selected by the curriculum committee, and the topics will change over time. The majority of the coursework will be programming assignments and readings.
Learning objectives
The student will learn and understand the most commonly used methodologies in the field of biomedical informatics.
Programming Languages
Learning the following programming languages during the duration of the course is required:
Course Assessment
- Programming Assignments (40%).
- Discussions (25%)
- Final Project (35%)
Lectures
Lecture 1 Course Overview (September 6, 2017 Alexandria West 508 5pm)
Lecturer: Fenyo
(
Slides
)
Homework (due date: September 11)
Lecture 2 Biomedical Data (September 11, 2017 Alexandria West 508 5pm)
Lecturer: Fenyo
(
Slides
)
Reading List
Goodwin et al., Coming of age: ten years of next-generation sequencing technologies. Nat Rev Genet. 17 (2016) 333-51.
Altelaar et al., Next-generation proteomics: towards an integrative view of proteome dynamics. Nat Rev Genet. 14 (2013) 35-48.
Combs CA, Shroff H., Fluorescence Microscopy: A Concise Guide to Current Imaging Methods. Curr Protoc Neurosci. 79 (2017) 2.1.1-2.1.25.
Cowie et al., Electronic health records to facilitate clinical research, Clin Res Cardiol. 106 (2017) 1–9.
Lecture 3 Data Visualization (September 13, 2017 Alexandria West 508 5pm)
Lecturer: Ruggles
(
Slides
)
Reading List
Schroeder et al. Genome Medicine 2013, 5:9
Data visualization: A view of every Points of View column
Additional Reading
The Wall Street Journal Guide to Information Graphics: The Dos and Don'ts of Presenting Data, Facts, and Figures
Visualize This: The FlowingData Guide to Design, Visualization, and Statistics by Nathan Yau
Lecture 4 Data Analysis (September 18, 2017 Alexandria West 508 5pm)
Lecturer: Ruggles
(
Slides
)
Reading List
Mertins et al., Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534 (2016) 55-62.
Bermudez-Hernandez et al., A Method for Quantifying Molecular Interactions Using Stochastic Modelling and Super-Resolution Microscopy, bioRxiv (2017)
Rotmensch et al., Learning a Health Knowledge Graph from Electronic Medical Records. Sci Rep. 7 (2017) 5994
Lecture 5 Algorithms (September 25, 2017 Alexandria West 508 5pm)
Lecturer: Kannan
(
Slides
)
Reading List
The Algorithm Design Manual by Steven S Skiena, Chapters 1-4
Visualgo
Additional Reading
Introduction to Algorithms, Third Edition by Thomas H. Cormen
Rosalind, Algorithm Heights
Coursera: Algorithms Part I
Coursera: Algorithms Part II
Lecture 6 Linear Algebra (September 27, 2017 Alexandria West 508 5pm)
Lecturer: Kannan
(
Slides
)
Reading List
Quick Review of Matrix and Real Linear Algebra by KC Border
Additional Reading
Coding the Matrix: Linear Algebra through Applications to Computer Science by Philip N. Klein
Linear Algebra and Its Applications, 4th Edition by Gilbert Strang
Lecture 7 Probability & Distributions (October 2, 2017 Alexandria West 508 5pm)
Lecturer: Jones
Lecture 8 Project Plan Presentations (October 16, 2017 Alexandria West 508 5pm)
Lecture 9 Signal Processing I: Introduction (October 18, 2017 Alexandria West 508 5pm)
Lecturer: Fenyo
(
Slides
)
Additional Reading
Coursera Digital Signal Processing
Lecture 10 Optimization (October 23, 2017 Alexandria West 508 5pm)
Lecturer: Kannan
(
Slides
)
Reading List
An Introduction to Optimization Chapers 6-9, 19, 20
Additional Reading
Coursera: Linear and Discrete Optimization
Lecture 11 Missing Data Imputation (October 30, 2017 Alexandria West 508 5pm)
Lecturer: Orwitz
(
Slides
)
Lecture 12 Signal Processing I: Introduction (cont.) (October 30, 2017 Alexandria West 508 6pm)
Lecturer: Fenyo
(
Slides
)
Homework (due date: November 15)
Lecture 13 Machine Learning (November 1, 2017 Alexandria West 508 5pm)
Lecturer: Fenyo
(
Slides
)
Additional Reading
Introduction to Statistical Learning: with Applications in R. James G, Witten D, Hastie T, Tibshirani R. Springer 2013
Lecture 14 Signal Processing II: Image Processing (November 6, 2017 Alexandria West 508 5pm)
Lecturer: Kannan
Lecture 15 Estimation & Hypothesis Testing (November 8, 2017 Alexandria West 508 5pm)
Lecturer: Jones
Lecture 15 Clinical Data (November 15, 2017 Alexandria West 508 5pm)
Lecturer: Aphinyanaphongs
Lecture 16 Experimental Design (December 4, 2017 Alexandria West 508 5pm)
Lecturer: Troxel
Reading List
Bias as a threat to the validity of cancer molecular-marker research by David F. Ransohoff, Nat Rev Cancer 5 (2005) 142-149
Adaptive clinical trials in oncology by Donald A. Berry, Nature Reviews Clinical Oncology 9 (2012) 199-207.
Additional Reading
Design and Analysis of Experiments by Douglas C. Montgomery
Essentials of Clinical Research by Stephen P. Glasser
Handbook for Good Clinical Research Practice (GPC - WHO)
Lecture 17 Modeling and Simulation (December 6, 2017 Alexandria West 508 5pm)
Lecturer: Fenyo
Lecture 18 Project Presentations (December 11, 2017 Alexandria West 508 5pm)
Lecture 19 Project Presentations (December 13, 2017 Alexandria West 508 5pm)
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